4HYF

Structural basis and SAR for OD 270, a lead stage 1,2,4-triazole based specific Tankyrase1/2 inhibitor

4HYF の概要

• エントリーDOI: 10.2210/pdb4hyf/pdb
• 関連するPDBエントリー: 3KR7 3KR8 3P0N 3U9Y 4HKI 4HKN
• 分子名称: Tankyrase-2, NICOTINAMIDE, ZINC ION, ... (5 entities in total)
• 機能のキーワード: catalytic fragment, parp, adp-ribosylation, ank repeat, chromosomal protein, glycosyltransferase, phosphorylation, telomere, transferase, translocation, transport, wnt-signalling, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q9H2K2
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 84051.77

構造登録者

Perdreau, H.,Ekblad, B.,Voronkov, A.,Holsworth, D.D.,Waaler, J.,Drewes, G.,Schueler, H.,Krauss, S.,Morth, J.P. (登録日: 2012-11-13, 公開日: 2013-03-20, 最終更新日: 2023-09-20)

• 主引用文献: Voronkov, A.,Holsworth, D.D.,Waaler, J.,Wilson, S.R.,Ekblad, B.,Perdreau-Dahl, H.,Dinh, H.,Drewes, G.,Hopf, C.,Morth, J.P.,Krauss, S.; Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor.; J.Med.Chem., 56:3012-3023, 2013; PubMed: 23473363; DOI: 10.1021/jm4000566

実験手法

X-RAY DIFFRACTION (2.8 Å)