4HXQ

Crystal structure of human Arginase-1 complexed with inhibitor 14

4HXQ の概要

• エントリーDOI: 10.2210/pdb4hxq/pdb
• 関連するPDBエントリー: 1D3V 2AEB 4HWW 4HZE
• 分子名称: Arginase-1, [(5R)-5-carboxy-5-(methylamino)-7-(piperidin-1-yl)heptyl](trihydroxy)borate(1-), MANGANESE (II) ION, ... (4 entities in total)
• 機能のキーワード: metalloenzyme, alpha/beta fold, hydrolase, arginine metabolism, manganese, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68701.85

構造登録者

Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Whitehouse, D.L.,Golebiowski, A.,Ji, M.,Zhang, M.,Beckett, P.,Sheeler, R.,Andreoli, M.,Conway, B.,Mahboubi, K.,Schroeter, H.,Van Zandt, M.C.,Podjarny, A. (登録日: 2012-11-12, 公開日: 2013-03-20, 最終更新日: 2023-09-20)

• 主引用文献: Van Zandt, M.C.,Whitehouse, D.L.,Golebiowski, A.,Ji, M.K.,Zhang, M.,Beckett, R.P.,Jagdmann, G.E.,Ryder, T.R.,Sheeler, R.,Andreoli, M.,Conway, B.,Mahboubi, K.,D'Angelo, G.,Mitschler, A.,Cousido-Siah, A.,Ruiz, F.X.,Howard, E.I.,Podjarny, A.D.,Schroeter, H.; Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.; J.Med.Chem., 56:2568-2580, 2013; PubMed: 23472952; DOI: 10.1021/jm400014c

実験手法

X-RAY DIFFRACTION (1.45 Å)