4HVC
Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue
Summary for 4HVC
Entry DOI | 10.2210/pdb4hvc/pdb |
Descriptor | Bifunctional glutamate/proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ... (6 entities in total) |
Functional Keywords | ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytosol : P07814 |
Total number of polymer chains | 2 |
Total formula weight | 120148.09 |
Authors | Zhou, H.,Sun, L.,Yang, X.L.,Schimmel, P. (deposition date: 2012-11-06, release date: 2013-01-02, Last modification date: 2024-02-28) |
Primary citation | Zhou, H.,Sun, L.,Yang, X.L.,Schimmel, P. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature, 494:121-124, 2012 Cited by PubMed: 23263184DOI: 10.1038/nature11774 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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