4HVC

Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue

4HVC の概要

• エントリーDOI: 10.2210/pdb4hvc/pdb
• 分子名称: Bifunctional glutamate/proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ... (6 entities in total)
• 機能のキーワード: ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytosol : P07814
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120148.09

構造登録者

Zhou, H.,Sun, L.,Yang, X.L.,Schimmel, P. (登録日: 2012-11-06, 公開日: 2013-01-02, 最終更新日: 2024-02-28)

• 主引用文献: Zhou, H.,Sun, L.,Yang, X.L.,Schimmel, P.; ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.; Nature, 494:121-124, 2012; PubMed: 23263184; DOI: 10.1038/nature11774

実験手法

X-RAY DIFFRACTION (2 Å)