4HRM

Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2

4HRM の概要

• エントリーDOI: 10.2210/pdb4hrm/pdb
• 関連するPDBエントリー: 1N8Z 1S78 3H3B 3MZW 4HRL 4HRN
• 分子名称: Domain I of receptor tyrosine-protein kinase erbB-2, Designed Ankyrin Repeat Protein 9_26 (2 entities in total)
• 機能のキーワード: transferase-de novo protein complex, transferase/de novo protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 81712.63

構造登録者

Jost, C.,Schilling, J.,Plueckthun, A. (登録日: 2012-10-28, 公開日: 2013-10-16, 最終更新日: 2023-11-08)

• 主引用文献: Jost, C.,Schilling, J.,Tamaskovic, R.,Schwill, M.,Honegger, A.,Plueckthun, A.; Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2.; Structure, 21:1-13, 2013; PubMed: 24095059; DOI: 10.1016/j.str.2013.08.020

実験手法

X-RAY DIFFRACTION (3.2 Å)