4HRM
Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2
Summary for 4HRM
Entry DOI | 10.2210/pdb4hrm/pdb |
Related | 1N8Z 1S78 3H3B 3MZW 4HRL 4HRN |
Descriptor | Domain I of receptor tyrosine-protein kinase erbB-2, Designed Ankyrin Repeat Protein 9_26 (2 entities in total) |
Functional Keywords | transferase-de novo protein complex, transferase/de novo protein |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626 |
Total number of polymer chains | 4 |
Total formula weight | 81712.63 |
Authors | Jost, C.,Schilling, J.,Plueckthun, A. (deposition date: 2012-10-28, release date: 2013-10-16, Last modification date: 2023-11-08) |
Primary citation | Jost, C.,Schilling, J.,Tamaskovic, R.,Schwill, M.,Honegger, A.,Plueckthun, A. Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2. Structure, 21:1-13, 2013 Cited by PubMed: 24095059DOI: 10.1016/j.str.2013.08.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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