4HPO

Crystal structure of RV144-elicited antibody CH58 in complex with V2 peptide

Summary for 4HPO

• Entry DOI: 10.2210/pdb4hpo/pdb
• Related: 4HPY 4HQQ
• Descriptor: CH58 Fab heavy chain, CH58 Fab light chain, Envelope glycoprotein gp160, ... (5 entities in total)
• Functional Keywords: immunoglobulin, immune system-viral protein complex, immune system/viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 50906.62

Authors

McLellan, J.S.,Gorman, J.,Haynes, B.F.,Kwong, P.D. (deposition date: 2012-10-24, release date: 2013-02-06, Last modification date: 2023-09-20)

• Primary citation: Liao, H.X.,Bonsignori, M.,Alam, S.M.,McLellan, J.S.,Tomaras, G.D.,Moody, M.A.,Kozink, D.M.,Hwang, K.K.,Chen, X.,Tsao, C.Y.,Liu, P.,Lu, X.,Parks, R.J.,Montefiori, D.C.,Ferrari, G.,Pollara, J.,Rao, M.,Peachman, K.K.,Santra, S.,Letvin, N.L.,Karasavvas, N.,Yang, Z.Y.,Dai, K.,Pancera, M.,Gorman, J.,Wiehe, K.,Nicely, N.I.,Rerks-Ngarm, S.,Nitayaphan, S.,Kaewkungwal, J.,Pitisuttithum, P.,Tartaglia, J.,Sinangil, F.,Kim, J.H.,Michael, N.L.,Kepler, T.B.,Kwong, P.D.,Mascola, J.R.,Nabel, G.J.,Pinter, A.,Zolla-Pazner, S.,Haynes, B.F.; Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2.; Immunity, 38:176-186, 2013; PubMed: 23313589; DOI: 10.1016/j.immuni.2012.11.011

Experimental method

X-RAY DIFFRACTION (1.694 Å)