4HN4

Tryptophan synthase in complex with alpha aminoacrylate E(A-A) form and the F9 inhibitor in the alpha site

4HN4 の概要

• エントリーDOI: 10.2210/pdb4hn4/pdb
• 関連するPDBエントリー: 1A5S 2J9X 4HPJ 4HPX
• 分子名称: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (8 entities in total)
• 機能のキーワード: lyase, carbon-oxygen lyase, tryptophan biosynthesis, salmonella, f9f, allosteric enzyme, amino-acid biosynthesis, aromatic amino acid biosynthesis, pyridoxal phosphate, alpha amino acrylate, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Salmonella enterica subsp. enterica serovar Typhimurium; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73372.79

構造登録者

Hilario, E.,Niks, D.,Dunn, M.F.,Mueller, L.J.,Fan, L. (登録日: 2012-10-18, 公開日: 2013-12-25, 最終更新日: 2023-09-20)

• 主引用文献: Niks, D.,Hilario, E.,Dierkers, A.,Ngo, H.,Borchardt, D.,Neubauer, T.J.,Fan, L.,Mueller, L.J.,Dunn, M.F.; Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states.; Biochemistry, 52:6396-6411, 2013; PubMed: 23952479; DOI: 10.1021/bi400795e

実験手法

X-RAY DIFFRACTION (1.64 Å)