4HLZ
Crystal Structure of Fab C179 in Complex with a H2N2 influenza virus hemagglutinin
Summary for 4HLZ
| Entry DOI | 10.2210/pdb4hlz/pdb |
| Descriptor | Hemagglutinin HA1, 1,2-ETHANEDIOL, Hemagglutinin HA2, ... (10 entities in total) |
| Functional Keywords | neutralizing antibodies, antibody affinity, antigens, epitopes, glycosylation, hemagglutinin glycoproteins, immunoglobulin fab fragments, h2n2 subtype, influenza vaccines, avian flu, envelope protein, viral protein-immune system complex, viral protein/immune system |
| Biological source | Influenza A virus More |
| Total number of polymer chains | 12 |
| Total formula weight | 319542.85 |
| Authors | Dreyfus, C.,Wilson, I.A. (deposition date: 2012-10-17, release date: 2013-04-17, Last modification date: 2020-07-29) |
| Primary citation | Dreyfus, C.,Ekiert, D.C.,Wilson, I.A. Structure of a classical broadly neutralizing stem antibody in complex with a pandemic h2 influenza virus hemagglutinin. J.Virol., 87:7149-7154, 2013 Cited by PubMed Abstract: We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those targeted by the recently identified human broadly neutralizing antibodies. C179 also inhibits the low-pH conformational change of the HA but uses a different angle of approach and both heavy and light chains. PubMed: 23552413DOI: 10.1128/JVI.02975-12 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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