4HLD

Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 11

4HLD の概要

• エントリーDOI: 10.2210/pdb4hld/pdb
• 関連するPDBエントリー: 4GFD 4GSY 4HDC 4HEJ 4HLC
• 分子名称: Thymidylate kinase, 1-[(3S)-1-{[3-(3-chlorophenoxy)-4-hydroxyphenyl]sulfonyl}piperidin-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione (3 entities in total)
• 機能のキーワード: tmk, kinase, thymidylate kinase, mrsa, pipiridine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Staphylococcus aureus subsp. aureus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47893.06

構造登録者

Olivier, N. (登録日: 2012-10-16, 公開日: 2012-10-31, 最終更新日: 2024-02-28)

• 主引用文献: Martinez-Botella, G.,Loch, J.T.,Green, O.M.,Kawatkar, S.P.,Olivier, N.B.,Boriack-Sjodin, P.A.,Keating, T.A.; Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK).; Bioorg.Med.Chem.Lett., 23:169-173, 2013; PubMed: 23206863; DOI: 10.1016/j.bmcl.2012.10.128

実験手法

X-RAY DIFFRACTION (2 Å)