4HJ0

Crystal structure of the human GIPr ECD in complex with Gipg013 Fab at 3-A resolution

Summary for 4HJ0

Entry DOI	10.2210/pdb4hj0/pdb
Descriptor	Gastric inhibitory polypeptide receptor, Gipg013 Fab, Antagonizing antibody to the GIP Receptor, Heavy chain, Gipg013 Fab, Antagonizing antibody to the GIP Receptor, Light chain (3 entities in total)
Functional Keywords	glucagon receptor sub-family recognition fold, immune system
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Multi-pass membrane protein: P48546
Total number of polymer chains	6
Total formula weight	124429.64
Authors	Madhurantakam, C.,Ravn, P.,Gruetter, M.G.,Jackson, R.H. (deposition date: 2012-10-12, release date: 2013-05-29, Last modification date: 2023-09-20)
Primary citation	Ravn, P.,Madhurantakam, C.,Kunze, S.,Matthews, E.,Priest, C.,O'Brien, S.,Collinson, A.,Papworth, M.,Fritsch-Fredin, M.,Jermutus, L.,Benthem, L.,Gruetter, M.,Jackson, R.H. Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor. J.Biol.Chem., 288:19760-19772, 2013 Cited by PubMed: 23689510 DOI: 10.1074/jbc.M112.426288 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation