4HGE

JAK2 kinase (JH1 domain) in complex with compound 8

4HGE の概要

• エントリーDOI: 10.2210/pdb4hge/pdb
• 分子名称: Tyrosine-protein kinase JAK2, N-[1-(3-chlorophenyl)-3-methyl-1H-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total)
• 機能のキーワード: protein kinase, phosphotransfer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endomembrane system; Peripheral membrane protein (By similarity): O60674
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71389.81

構造登録者

Eigenbrot, C.,Ultsch, M. (登録日: 2012-10-08, 公開日: 2012-10-24, 最終更新日: 2023-12-06)

• 主引用文献: Hanan, E.J.,van Abbema, A.,Barrett, K.,Blair, W.S.,Blaney, J.,Chang, C.,Eigenbrot, C.,Flynn, S.,Gibbons, P.,Hurley, C.A.,Kenny, J.R.,Kulagowski, J.,Lee, L.,Magnuson, S.R.,Morris, C.,Murray, J.,Pastor, R.M.,Rawson, T.,Siu, M.,Ultsch, M.,Zhou, A.,Sampath, D.,Lyssikatos, J.P.; Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.; J.Med.Chem., 55:10090-10107, 2012; PubMed: 23061660; DOI: 10.1021/jm3012239

実験手法

X-RAY DIFFRACTION (2.3 Å)