Summary for 4HEI
| Entry DOI | 10.2210/pdb4hei/pdb |
| Related | 4FYL |
| Descriptor | RIBOSOME HIBERNATION PROTEIN YHBH, COBALT (III) ION, THIOCYANATE ION, ... (5 entities in total) |
| Functional Keywords | beta-alpha-beta-beta-beta-alpha secondary structure fold similar to yfia of e. coli, associates with 100s ribosome dimers, stationary phase, translation inhibition, translation, drbd, double-stranded rna binding domain, inhibits translation by binding the 30s ribosome |
| Biological source | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
| Total number of polymer chains | 2 |
| Total formula weight | 22947.53 |
| Authors | De Bari, H.,Berry, E.A. (deposition date: 2012-10-03, release date: 2012-10-24, Last modification date: 2024-02-28) |
| Primary citation | De Bari, H.,Berry, E.A. Structure of Vibrio cholerae ribosome hibernation promoting factor. Acta Crystallogr.,Sect.F, 69:228-236, 2013 Cited by PubMed Abstract: The X-ray crystal structure of ribosome hibernation promoting factor (HPF) from Vibrio cholerae is presented at 2.0 Å resolution. The crystal was phased by two-wavelength MAD using cocrystallized cobalt. The asymmetric unit contained two molecules of HPF linked by four Co atoms. The metal-binding sites observed in the crystal are probably not related to biological function. The structure of HPF has a typical β-α-β-β-β-α fold consistent with previous structures of YfiA and HPF from Escherichia coli. Comparison of the new structure with that of HPF from E. coli bound to the Thermus thermophilus ribosome [Polikanov et al. (2012), Science, 336, 915-918] shows that no significant structural changes are induced in HPF by binding. PubMed: 23519794DOI: 10.1107/S1744309113000961 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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