4HBX
Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand
4HBX の概要
エントリーDOI | 10.2210/pdb4hbx/pdb |
関連するPDBエントリー | 4HBV 4HBW 4HBY |
分子名称 | Bromodomain-containing protein 4, 3-methyl-6-(pyrrolidin-1-ylsulfonyl)-3,4-dihydroquinazolin-2(1H)-one (3 entities in total) |
機能のキーワード | bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, structural genomics consortium, sgc, protein binding/inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus (By similarity): O60885 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 15394.74 |
構造登録者 | Filippakopoulos, P.,Picaud, S.,Qi, J.,Felletar, I.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Fish, P.V.,Bunnage, M.E.,Cook, A.S.,Owen, D.R.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2012-09-28, 公開日: 2012-10-31, 最終更新日: 2023-09-20) |
主引用文献 | Fish, P.V.,Filippakopoulos, P.,Bish, G.,Brennan, P.E.,Bunnage, M.E.,Cook, A.S.,Federov, O.,Gerstenberger, B.S.,Jones, H.,Knapp, S.,Marsden, B.,Nocka, K.,Owen, D.R.,Philpott, M.,Picaud, S.,Primiano, M.J.,Ralph, M.J.,Sciammetta, N.,Trzupek, J.D. Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit. J.Med.Chem., 55:9831-9837, 2012 Cited by PubMed: 23095041DOI: 10.1021/jm3010515 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.62 Å) |
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