4HAX
Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1(K579A)-Ran-RanBP1
Summary for 4HAX
Entry DOI | 10.2210/pdb4hax/pdb |
Related | 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4 |
Descriptor | Exportin-1, GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, ... (10 entities in total) |
Functional Keywords | heat repeat, nuclear export, ran-ranbp1, ratjadone a, protein transport-antibiotic complex, protein transport/antibiotic |
Biological source | Saccharomyces cerevisiae (yeast) More |
Cellular location | Nucleus : P30822 P62826 Cytoplasm: P41920 |
Total number of polymer chains | 3 |
Total formula weight | 159767.65 |
Authors | Sun, Q.,Chook, Y.M. (deposition date: 2012-09-27, release date: 2013-01-09, Last modification date: 2017-07-26) |
Primary citation | Sun, Q.,Carrasco, Y.P.,Hu, Y.,Guo, X.,Mirzaei, H.,Macmillan, J.,Chook, Y.M. Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110:1303-1308, 2013 Cited by PubMed: 23297231DOI: 10.1073/pnas.1217203110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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