4H8W
Crystal structure of non-neutralizing and ADCC-potent antibody N5-i5 in complex with HIV-1 clade A/E gp120 and sCD4.
Summary for 4H8W
Entry DOI | 10.2210/pdb4h8w/pdb |
Related | 1G9M 3TGT 3TNN |
Descriptor | HIV-1 CLADE A/E 93TH057 (H375S) GP120, FAB HEAVY CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, FAB LIGHT CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, ... (8 entities in total) |
Functional Keywords | hiv-1 gp120, clade a/e 93th057, viral protein, viral protein-immune system complex, viral protein/immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 109055.17 |
Authors | Tolbert, W.D.,Acharya, P.,Kwong, P.D.,Pazgier, M. (deposition date: 2012-09-24, release date: 2014-04-09, Last modification date: 2023-09-20) |
Primary citation | Acharya, P.,Tolbert, W.D.,Gohain, N.,Wu, X.,Yu, L.,Liu, T.,Huang, W.,Huang, C.C.,Kwon, Y.D.,Louder, R.K.,Luongo, T.S.,McLellan, J.S.,Pancera, M.,Yang, Y.,Zhang, B.,Flinko, R.,Foulke, J.S.,Sajadi, M.M.,Kamin-Lewis, R.,Robinson, J.E.,Martin, L.,Kwong, P.D.,Guan, Y.,DeVico, A.L.,Lewis, G.K.,Pazgier, M. Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection. J.Virol., 88:12895-12906, 2014 Cited by PubMed: 25165110DOI: 10.1128/JVI.02194-14 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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