4H8W
Crystal structure of non-neutralizing and ADCC-potent antibody N5-i5 in complex with HIV-1 clade A/E gp120 and sCD4.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (G) | HIV-1 CLADE A/E 93TH057 (H375S) GP120 | polymer | 353 | 39160.4 | 1 | UniProt (by SIFTS) (Q0ED31) | Homo sapiens | |
| 2 | B (H) | FAB HEAVY CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5 | polymer | 226 | 23789.6 | 1 | Homo sapiens | ||
| 3 | C (L) | FAB LIGHT CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5 | polymer | 217 | 22943.2 | 1 | Homo sapiens | ||
| 4 | D (C) | T-cell surface glycoprotein CD4 | polymer | 185 | 20503.3 | 1 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) | Homo sapiens (human) | T-cell surface antigen T4/Leu-3 |
| 5 | E, F, G, H, I... (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
| 6 | O, P, Q (G, L) | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 3 | Chemie (MRD) PubChem (7870) PubChem (5288834) PubChem (5288845) | |||
| 7 | R (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 8 | S, T, U, V (G, H, L, C) | water | water | 18.0 | 762 | Chemie (HOH) |
Sequence modifications
C: 1 - 183 (UniProt: P01730)
| PDB | External Database | Details |
|---|---|---|
| Asn 184 | - | expression tag |
| Thr 185 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 106396.5 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2658.7 | |
| All* | Total formula weight | 109055.2 |
