4H6S
Crystal structure of thrombin mutant E14eA/D14lA/E18A/S195A
Summary for 4H6S
Entry DOI | 10.2210/pdb4h6s/pdb |
Related | 1SHH 4H6T |
Descriptor | Prothrombin, SODIUM ION, ... (4 entities in total) |
Functional Keywords | serine protease, prethrombin-2, autoactivation, hydrolase, hydrolase-peptide complex, hydrolase/peptide |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 2 |
Total formula weight | 33274.20 |
Authors | Pozzi, N.,Chen, Z.,Zapata, F.,Pelc, L.A.,Di Cera, E. (deposition date: 2012-09-19, release date: 2013-03-13, Last modification date: 2023-09-20) |
Primary citation | Pozzi, N.,Chen, Z.,Zapata, F.,Niu, W.,Barranco-Medina, S.,Pelc, L.A.,Di Cera, E. Autoactivation of thrombin precursors. J.Biol.Chem., 288:11601-11610, 2013 Cited by PubMed: 23467412DOI: 10.1074/jbc.M113.451542 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)