4H6S
Crystal structure of thrombin mutant E14eA/D14lA/E18A/S195A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Prothrombin | polymer | 31 | 3545.0 | 1 | UniProt (P00734) Pfam (PF09396) In PDB | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
2 | B | Prothrombin | polymer | 259 | 29706.2 | 1 | UniProt (P00734) Pfam (PF00089) In PDB | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
3 | B | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
4 | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 1 - 15 (UniProt: P00734)
B: 16 - 247 (UniProt: P00734)
PDB | External Database | Details |
---|---|---|
Ala 14 | Glu 354 | engineered mutation |
Ala 14 | Asp 361 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 18 | Glu 366 | engineered mutation |
Ala 195 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 33251.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 23.0 | |
All* | Total formula weight | 33274.2 |