4H42

Synthesis of a Weak Basic uPA Inhibitor and Crystal Structure of Complex with uPA

Summary for 4H42

• Entry DOI: 10.2210/pdb4h42/pdb
• Related: 3MHW
• Descriptor: Urokinase-type plasminogen activator, N-[(2-amino-1,3-benzothiazol-6-yl)carbonyl]glycine, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, ... (4 entities in total)
• Functional Keywords: hydrolase, plasminogen activation, protease, serine protease, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P00749
• Total number of polymer chains: 1
• Total formula weight: 28491.42

Authors

Yu, H.-Y.,Gao, D.,Zhang, X.,Jiang, L.-G.,Hong, Z.-B.,Yuan, C.,Fang, X.,Wang, J.-D.,Huang, M.-D. (deposition date: 2012-09-14, release date: 2013-10-30, Last modification date: 2023-12-27)

• Primary citation: Yu, H.-Y.,Gao, D.,Xu, Z.,Jiang, L.-G.,Hong, Z.-B.,Fan, X.,Yuan, C.,Wang, J.-D.,Huang, M.; Synthesis of a Weak Basic uPA Inhibitor and Crystal Structure of Complex with uPA; CHIN.J.STRUCT.CHEM., 32:961-968, 2013

Experimental method

X-RAY DIFFRACTION (2.01 Å)