4H42
Synthesis of a Weak Basic uPA Inhibitor and Crystal Structure of Complex with uPA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | U | Urokinase-type plasminogen activator | polymer | 248 | 27973.8 | 1 | UniProt (P00749) Pfam (PF00089) In PDB | Homo sapiens (human) | U-plasminogen activator, uPA, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B |
| 2 | U | N-[(2-amino-1,3-benzothiazol-6-yl)carbonyl]glycine | non-polymer | 251.3 | 1 | Chemie (11E) | |||
| 3 | U | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE | non-polymer | 266.3 | 1 | Chemie (PG6) | |||
| 4 | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
U: 16 - 245 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27973.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 517.6 | |
| All* | Total formula weight | 28491.4 |
