4H12

The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine

「3H6L」から置き換えられました

4H12 の概要

• エントリーDOI: 10.2210/pdb4h12/pdb
• 分子名称: Histone-lysine N-methyltransferase SETD2, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• 機能のキーワード: methyltransferase, set domain-containing protein 2, s-adenosyl-l-homocysteine, structural genomics, structural genomics consortium, sgc, activator, chromatin regulator, dna-binding, methylation, nucleus, phosphoprotein, transcription, transcription regulation, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (Probable): Q9BYW2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32571.58

構造登録者

Amaya, M.F.,Dong, A.,Zeng, H.,Mackenzie, F.,Bunnage, M.,Weigelt, J.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Wu, H.,Structural Genomics Consortium (SGC) (登録日: 2012-09-10, 公開日: 2012-10-03, 最終更新日: 2023-09-13)

• 主引用文献: Zheng, W.,Ibanez, G.,Wu, H.,Blum, G.,Zeng, H.,Dong, A.,Li, F.,Hajian, T.,Allali-Hassani, A.,Amaya, M.F.,Siarheyeva, A.,Yu, W.,Brown, P.J.,Schapira, M.,Vedadi, M.,Min, J.,Luo, M.; Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2.; J.Am.Chem.Soc., 134:18004-18014, 2012; PubMed: 23043551; DOI: 10.1021/ja307060p

実験手法