4H12
The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine
「3H6L」から置き換えられました4H12 の概要
エントリーDOI | 10.2210/pdb4h12/pdb |
分子名称 | Histone-lysine N-methyltransferase SETD2, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total) |
機能のキーワード | methyltransferase, set domain-containing protein 2, s-adenosyl-l-homocysteine, structural genomics, structural genomics consortium, sgc, activator, chromatin regulator, dna-binding, methylation, nucleus, phosphoprotein, transcription, transcription regulation, transferase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus (Probable): Q9BYW2 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 32571.58 |
構造登録者 | Amaya, M.F.,Dong, A.,Zeng, H.,Mackenzie, F.,Bunnage, M.,Weigelt, J.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Wu, H.,Structural Genomics Consortium (SGC) (登録日: 2012-09-10, 公開日: 2012-10-03, 最終更新日: 2023-09-13) |
主引用文献 | Zheng, W.,Ibanez, G.,Wu, H.,Blum, G.,Zeng, H.,Dong, A.,Li, F.,Hajian, T.,Allali-Hassani, A.,Amaya, M.F.,Siarheyeva, A.,Yu, W.,Brown, P.J.,Schapira, M.,Vedadi, M.,Min, J.,Luo, M. Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2. J.Am.Chem.Soc., 134:18004-18014, 2012 Cited by PubMed: 23043551DOI: 10.1021/ja307060p 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.06 Å) |
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