4GXY

RNA structure

4GXY の概要

• エントリーDOI: 10.2210/pdb4gxy/pdb
• 分子名称: Adenosylcobalamin riboswitch, Adenosylcobalamin, IRIDIUM HEXAMMINE ION, ... (5 entities in total)
• 機能のキーワード: rna, riboswitch, adenosylcobalamin
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61457.90

構造登録者

Serganov, A.,Peselis, A. (登録日: 2012-09-04, 公開日: 2012-10-17, 最終更新日: 2024-02-28)

主引用文献

Peselis, A.,Serganov, A.
Structural insights into ligand binding and gene expression control by an adenosylcobalamin riboswitch.
Nat.Struct.Mol.Biol., 19:1182-1184, 2012

PubMed Abstract: Coenzyme B(12) has a key role in various enzymatic reactions and controls expression of bacterial genes through riboswitches. Here we report the crystal structure of the Symbiobacterium thermophilum B(12) riboswitch bound to its ligand adenosylcobalamin. The riboswitch forms a unique junctional structure with a large ligand-binding pocket tailored for specific recognition of the adenosyl moiety and flanked by structural elements that stabilize the regulatory region and enable control of gene expression.

PubMed: 23064646
DOI: 10.1038/nsmb.2405

実験手法

X-RAY DIFFRACTION (3.05 Å)