4GV7

Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328

Summary for 4GV7

Entry DOI	10.2210/pdb4gv7/pdb
Descriptor	Poly [ADP-ribose] polymerase 1, 2-methylquinazolin-4(3H)-one (2 entities in total)
Functional Keywords	nad, adp-ribose, parp1, artd1, artd transferase domain, adp-ribosylation, transferase-transferase inhibitor complex, adp-ribose transferase, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P09874
Total number of polymer chains	4
Total formula weight	161440.49
Authors	Karlberg, T.,Thorsell, A.G.,Lindgren, A.E.G.,Ekblad, T.,Spjut, S.,Andersson, C.D.,Weigelt, J.,Linusson, A.,Elofsson, M.,Schuler, H. (deposition date: 2012-08-30, release date: 2013-06-19, Last modification date: 2023-11-08)
Primary citation	Lindgren, A.E.G.,Karlberg, T.,Thorsell, A.G.,Hesse, M.,Spjut, S.,Ekblad, T.,Andersson, C.D.,Pinto, A.F.,Weigelt, J.,Hottiger, M.O.,Linusson, A.,Elofsson, M.,Schuler, H. PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3 Acs Chem.Biol., 8:1698-1703, 2013 Cited by PubMed: 23742272 DOI: 10.1021/cb4002014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.89 Å)

Structure validation