4GV7

Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328

4GV7 の概要

• エントリーDOI: 10.2210/pdb4gv7/pdb
• 分子名称: Poly [ADP-ribose] polymerase 1, 2-methylquinazolin-4(3H)-one (2 entities in total)
• 機能のキーワード: nad, adp-ribose, parp1, artd1, artd transferase domain, adp-ribosylation, transferase-transferase inhibitor complex, adp-ribose transferase, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P09874
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 161440.49

構造登録者

Karlberg, T.,Thorsell, A.G.,Lindgren, A.E.G.,Ekblad, T.,Spjut, S.,Andersson, C.D.,Weigelt, J.,Linusson, A.,Elofsson, M.,Schuler, H. (登録日: 2012-08-30, 公開日: 2013-06-19, 最終更新日: 2023-11-08)

• 主引用文献: Lindgren, A.E.G.,Karlberg, T.,Thorsell, A.G.,Hesse, M.,Spjut, S.,Ekblad, T.,Andersson, C.D.,Pinto, A.F.,Weigelt, J.,Hottiger, M.O.,Linusson, A.,Elofsson, M.,Schuler, H.; PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3; Acs Chem.Biol., 8:1698-1703, 2013; PubMed: 23742272; DOI: 10.1021/cb4002014

実験手法

X-RAY DIFFRACTION (2.89 Å)