4GV1
PKB alpha in complex with AZD5363
Summary for 4GV1
Entry DOI | 10.2210/pdb4gv1/pdb |
Descriptor | RAC-alpha serine/threonine-protein kinase, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P31749 |
Total number of polymer chains | 1 |
Total formula weight | 40191.15 |
Authors | Addie, M.,Ballard, P.,Bird, G.,Buttar, D.,Currie, G.,Davies, B.,Debreczeni, J.,Dry, H.,Dudley, P.,Greenwood, R.,Hatter, G.,Jestel, A.,Johnson, P.D.,Kettle, J.G.,Lane, C.,Lamont, G.,Leach, A.,Luke, R.W.A.,Ogilvie, D.,Page, K.,Pass, M.,Steinbacher, S.,Steuber, H.,Pearson, S.,Ruston, L. (deposition date: 2012-08-30, release date: 2013-02-27, Last modification date: 2017-11-15) |
Primary citation | Addie, M.,Ballard, P.,Buttar, D.,Crafter, C.,Currie, G.,Davies, B.R.,Debreczeni, J.,Dry, H.,Dudley, P.,Greenwood, R.,Johnson, P.D.,Kettle, J.G.,Lane, C.,Lamont, G.,Leach, A.,Luke, R.W.,Morris, J.,Ogilvie, D.,Page, K.,Pass, M.,Pearson, S.,Ruston, L. Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases. J.Med.Chem., 56:2059-2073, 2013 Cited by PubMed: 23394218DOI: 10.1021/jm301762v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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