4GU9

Focal adhesion kinase catalytic domain in complex with (2-Fluoro-phenyl)-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)-amine

4GU9 の概要

• エントリーDOI: 10.2210/pdb4gu9/pdb
• 分子名称: Focal adhesion kinase 1, N-(2-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
• 機能のキーワード: protein tyrosine kinase, transferase, atp binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell junction, focal adhesion: Q05397
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64374.28

構造登録者

Musil, D. (登録日: 2012-08-29, 公開日: 2013-09-04, 最終更新日: 2023-09-13)

• 主引用文献: Heinrich, T.,Seenisamy, J.,Emmanuvel, L.,Kulkarni, S.S.,Bomke, J.,Rohdich, F.,Greiner, H.,Esdar, C.,Krier, M.,Gradler, U.,Musil, D.; Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors.; J.Med.Chem., 56:1160-1170, 2013; PubMed: 23294348; DOI: 10.1021/jm3016014

実験手法

X-RAY DIFFRACTION (2.4 Å)