4GU4

Crystal structure of the T1L reovirus attachment protein sigma1 in complex with alpha-2,3-sialyllactose

Summary for 4GU4

• Entry DOI: 10.2210/pdb4gu4/pdb
• Related: 1KKE 3S6X 4GU3
• Descriptor: Outer capsid protein sigma-1, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose (3 entities in total)
• Functional Keywords: triple beta-spiral, beta-barrel, beta-spiral repeat, greek key motif, viral attachment protein, gm2 glycan alpha-2, 3-sialyllactose junctional adhesion molecule a, viral capsid, viral protein
• Biological source: Mammalian orthoreovirus 1 (T1L)
• Cellular location: Virion (By similarity): P04506
• Total number of polymer chains: 3
• Total formula weight: 75239.92

Authors

Reiss, K.,Stehle, T. (deposition date: 2012-08-29, release date: 2012-12-05, Last modification date: 2024-02-28)

• Primary citation: Reiss, K.,Stencel, J.E.,Liu, Y.,Blaum, B.S.,Reiter, D.M.,Feizi, T.,Dermody, T.S.,Stehle, T.; The GM2 Glycan Serves as a Functional Coreceptor for Serotype 1 Reovirus.; Plos Pathog., 8:e1003078-e1003078, 2012; PubMed: 23236285; DOI: 10.1371/journal.ppat.1003078

Experimental method

X-RAY DIFFRACTION (3.5 Å)