4GTR

FTase in complex with BMS analogue 13

Summary for 4GTR

Entry DOI	10.2210/pdb4gtr/pdb
Related	4GTM 4GTO 4GTP 4GTQ 4GTS 4GTT 4GTV
Descriptor	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, DIMETHYL SULFOXIDE, ... (7 entities in total)
Functional Keywords	protein prenylation, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Rattus norvegicus (rat) More
Total number of polymer chains	2
Total formula weight	93172.39
Authors	Guo, Z.,Stigter, E.A.,Bon, R.S.,Waldmann, H.,Blankenfeldt, W.,Goody, R.S. (deposition date: 2012-08-29, release date: 2012-10-24, Last modification date: 2023-11-08)
Primary citation	Stigter, E.A.,Guo, Z.,Bon, R.S.,Wu, Y.W.,Choidas, A.,Wolf, A.,Menninger, S.,Waldmann, H.,Blankenfeldt, W.,Goody, R.S. Development of Selective, Potent RabGGTase Inhibitors J.Med.Chem., 55:8330-8340, 2012 Cited by PubMed: 22963166 DOI: 10.1021/jm300624s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation