4GRT
HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME
Summary for 4GRT
Entry DOI | 10.2210/pdb4grt/pdb |
Descriptor | GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE (3 entities in total) |
Functional Keywords | oxidoreductase, flavoenzyme, mixed disulfide |
Biological source | Homo sapiens (human) |
Cellular location | Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390 |
Total number of polymer chains | 1 |
Total formula weight | 51574.89 |
Authors | Stoll, V.S.,Simpson, S.J.,Krauth-Siegel, R.L.,Walsh, C.T.,Pai, E.F. (deposition date: 1997-02-12, release date: 1997-08-12, Last modification date: 2023-08-09) |
Primary citation | Stoll, V.S.,Simpson, S.J.,Krauth-Siegel, R.L.,Walsh, C.T.,Pai, E.F. Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry, 36:6437-6447, 1997 Cited by PubMed: 9174360DOI: 10.1021/bi963074p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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