4GRT

HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME

4GRT の概要

• エントリーDOI: 10.2210/pdb4grt/pdb
• 分子名称: GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE (3 entities in total)
• 機能のキーワード: oxidoreductase, flavoenzyme, mixed disulfide
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51574.89

構造登録者

Stoll, V.S.,Simpson, S.J.,Krauth-Siegel, R.L.,Walsh, C.T.,Pai, E.F. (登録日: 1997-02-12, 公開日: 1997-08-12, 最終更新日: 2023-08-09)

• 主引用文献: Stoll, V.S.,Simpson, S.J.,Krauth-Siegel, R.L.,Walsh, C.T.,Pai, E.F.; Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.; Biochemistry, 36:6437-6447, 1997; PubMed: 9174360; DOI: 10.1021/bi963074p

実験手法

X-RAY DIFFRACTION (2.8 Å)