4GRL

Crystal structure of a autoimmune TCR-MHC complex

Summary for 4GRL

• Entry DOI: 10.2210/pdb4grl/pdb
• Related: 3PL6 4MAY
• Descriptor: MHC class II HLA-DQ-alpha chain, MHC class II antigen, TCR Hy.1B11 alpha chain, ... (6 entities in total)
• Functional Keywords: immune complex, peptide antigen presentation, multiple sclerosis, autoimmunity, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 97019.84

Authors

Sethi, D.K.,Wucherpfennig, K.W. (deposition date: 2012-08-25, release date: 2013-11-06, Last modification date: 2020-07-29)

• Primary citation: Sethi, D.K.,Gordo, S.,Schubert, D.A.,Wucherpfennig, K.W.; Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop.; Nat Commun, 4:2623-2623, 2013; PubMed: 24136005; DOI: 10.1038/ncomms3623

Experimental method

X-RAY DIFFRACTION (2.86 Å)