4GRB

Casein kinase 2 (CK2) bound to inhibitor

4GRB の概要

• エントリーDOI: 10.2210/pdb4grb/pdb
• 関連するPDBエントリー: 3U4U
• 分子名称: Casein kinase II subunit alpha, CHLORIDE ION, 5-(2-{[4-(dimethylcarbamoyl)phenyl]amino}-4-methoxypyrimidin-5-yl)thiophene-3-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: kinase, protein kinase, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40312.39

構造登録者

Larsen, N.A.,Dowling, J.E.,Ferguson, A.D. (登録日: 2012-08-24, 公開日: 2013-08-28, 最終更新日: 2024-02-28)

• 主引用文献: Dowling, J.E.,Alimzhanov, M.,Bao, L.,Block, M.H.,Chuaqui, C.,Cooke, E.L.,Denz, C.R.,Hird, A.,Huang, S.,Larsen, N.A.,Peng, B.,Pontz, T.W.,Rivard-Costa, C.,Saeh, J.C.,Thakur, K.,Ye, Q.,Zhang, T.,Lyne, P.D.; Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.; ACS Med Chem Lett, 4:800-805, 2013; PubMed: 24900749; DOI: 10.1021/ml400197u

実験手法

X-RAY DIFFRACTION (2.15 Å)