4GR9

Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation

Summary for 4GR9

• Entry DOI: 10.2210/pdb4gr9/pdb
• Related: 4GQI
• Descriptor: Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
• Functional Keywords: melatonin analog, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P16083
• Total number of polymer chains: 2
• Total formula weight: 53979.21

Authors

Volkova, M.S.,Jensen, K.C.,Lozinskaya, N.A.,Sosonyuk, S.E.,Proskurnina, M.V.,Mesecar, A.D.,Zefirov, N.S. (deposition date: 2012-08-24, release date: 2013-07-10, Last modification date: 2024-02-28)

• Primary citation: Volkova, M.S.,Jensen, K.C.,Lozinskaya, N.A.,Sosonyuk, S.E.,Proskurnina, M.V.,Mesecar, A.D.,Zefirov, N.S.; Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation.; Bioorg.Med.Chem.Lett., 22:7578-7581, 2012; PubMed: 23131339; DOI: 10.1016/j.bmcl.2012.10.005

Experimental method

X-RAY DIFFRACTION (2.291 Å)