4GQJ

Complex of a binuclear Ruthenium compound D,D-([mu-(11,11')-bi(dppz)-(1,10-phenanthroline)4-Ru2]4+) bound to d(CGTACG)

Summary for 4GQJ

• Entry DOI: 10.2210/pdb4gqj/pdb
• Related: 3qrn 3s80 3u38 4e1u 4e7y
• Descriptor: DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), (mu-11,11'-bidipyrido[3,2-a:2',3'-c]phenazine-1kappa~2~N~4~,N~5~:2kappa~2~N~4'~,N~5'~)[tetrakis(1,10-phenanthroline-kappa~2~N~1~,N~10~)]diruthenium (3 entities in total)
• Functional Keywords: dna recognition, dna binsinf, dna
• Total number of polymer chains: 2
• Total formula weight: 5103.98

Authors

Boer, D.R.,Coll, M. (deposition date: 2012-08-23, release date: 2014-03-05, Last modification date: 2024-03-13)

Primary citation

Boer, D.R.,Wu, L.,Lincoln, P.,Coll, M.
Thread Insertion of a Bis(dipyridophenazine) Diruthenium Complex into the DNA Double Helix by the Extrusion of AT Base Pairs and Cross-Linking of DNA Duplexes.
Angew.Chem.Int.Ed.Engl., 53:1949-1952, 2014

PubMed Abstract: The crystal structure of the Δ,Δ enantiomer of the binuclear "light-switch" ruthenium complex [μ-(11,11'-bidppz)(1,10-phenanthroline)4  Ru2 ](4+) bound to the oligonucleotide d(CGTACG) shows that one dppz moiety of the dumbbell-like compound inserts into the DNA stack through the extrusion of an AT base pair. The second dppz moiety recruits a neighboring DNA molecule, and the complex thus cross-links two adjacent duplexes by bridging their major grooves.

PubMed: 24449275
DOI: 10.1002/anie.201308070

Experimental method

X-RAY DIFFRACTION (2.951 Å)