4GPW

Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P21212 form)

Summary for 4GPW

• Entry DOI: 10.2210/pdb4gpw/pdb
• Related: 2F8U 2F8V 4GPX 4GPY
• Descriptor: RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'), (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(hydroxymethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside (3 entities in total)
• Functional Keywords: ribosome, aminoglycoside, rna-antibiotic complex, antiprotozoal activity, antibacterial activity, rna/antibiotic
• Total number of polymer chains: 2
• Total formula weight: 15669.87

Authors

Kondo, J.,Koganei, M.,Maianti, J.P.,Ly, V.L.,Hanessian, S. (deposition date: 2012-08-22, release date: 2013-04-03, Last modification date: 2024-03-20)

• Primary citation: Kondo, J.,Koganei, M.,Maianti, J.P.,Ly, V.L.,Hanessian, S.; Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites; Chemmedchem, 8:733-739, 2013; PubMed: 23436717; DOI: 10.1002/cmdc.201200579

Experimental method

X-RAY DIFFRACTION (3 Å)