4GHA
Crystal structure of Marburg virus VP35 RNA binding domain bound to 12-bp dsRNA
Summary for 4GHA
Entry DOI | 10.2210/pdb4gha/pdb |
Related | 3FKE 3L25 3L26 3LA2 3SK8 4GH9 |
Descriptor | Polymerase cofactor VP35, RNA (5'-R(*CP*UP*AP*GP*AP*CP*GP*UP*CP*UP*AP*G)-3') (3 entities in total) |
Functional Keywords | viral polymerase, interferon inhibition, dsrna, viral protein, rna binding protein-rna complex, rna binding protein/rna |
Biological source | Marburg virus - Musoke, Kenya, 1980 (MARV) More |
Cellular location | Virion: P35259 |
Total number of polymer chains | 6 |
Total formula weight | 72835.05 |
Authors | Bale, S.,Jean-Philippe, J.,Bornholdt, Z.A.,Kimberlin, C.K.,Halfmann, P.,Zandonatti, M.A.,Kunert, J.,Kroon, G.J.A.,Kawaoka, Y.,MacRae, I.J.,Wilson, I.A.,Saphire, E.O. (deposition date: 2012-08-07, release date: 2012-08-22, Last modification date: 2023-09-13) |
Primary citation | Bale, S.,Julien, J.P.,Bornholdt, Z.A.,Kimberlin, C.R.,Halfmann, P.,Zandonatti, M.A.,Kunert, J.,Kroon, G.J.,Kawaoka, Y.,Macrae, I.J.,Wilson, I.A.,Saphire, E.O. Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism. Plos Pathog., 8:e1002916-e1002916, 2012 Cited by PubMed: 23028316DOI: 10.1371/journal.ppat.1002916 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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