4GH7

Crystal structure of Anticalin N7A in complex with oncofetal fibronectin fragment Fn7B8

4GH7 の概要

• エントリーDOI: 10.2210/pdb4gh7/pdb
• 分子名称: Neutrophil gelatinase-associated lipocalin, Fibronectin (3 entities in total)
• 機能のキーワード: lipocalin, anticalin, human fibronectin, fn type iii domain, oncofetal fibronectin splice variant p02751-7, lipocalin-based binding protein, extra-domain b, eiiib, ed-b, extracellular matrix, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted : P80188; Secreted, extracellular space, extracellular matrix: P02751
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 105920.04

構造登録者

Schiefner, A.,Gebauer, M.,Skerra, A. (登録日: 2012-08-07, 公開日: 2012-12-26, 最終更新日: 2023-11-08)

• 主引用文献: Gebauer, M.,Schiefner, A.,Matschiner, G.,Skerra, A.; Combinatorial design of an Anticalin directed against the extra-domain b for the specific targeting of oncofetal fibronectin; J.Mol.Biol., 425:780-802, 2013; PubMed: 23238252; DOI: 10.1016/j.jmb.2012.12.004

実験手法

X-RAY DIFFRACTION (2.6 Å)