4GH4

Crystal Structure of Foot and Mouth Disease Virus A22 Serotype

Summary for 4GH4

Entry DOI	10.2210/pdb4gh4/pdb
Related	1BBT 1FMD
Descriptor	capsid protein VP1, capsid protein VP2, capsid protein VP3, ... (5 entities in total)
Functional Keywords	icosahedral virus, capsids, picornavirus, apthovirus, virus
Biological source	Foot-and-mouth disease virus - type A More
Total number of polymer chains	4
Total formula weight	75510.98
Authors	Kotecha, A.,Jinshan, R.,Curry, S.,Fry, E.,Stuart, D. (deposition date: 2012-08-07, release date: 2013-02-20, Last modification date: 2024-02-28)
Primary citation	Curry, S.,Fry, E.,Blakemore, W.,Abu-Ghazaleh, R.,Jackson, T.,King, A.,Lea, S.,Newman, J.,Rowlands, D.,Stuart, D. Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity. Structure, 4:135-145, 1996 Cited by PubMed Abstract: Foot-and-mouth disease virus (FMDV) is an extremely infectious and antigenically diverse picornavirus of cloven-hoofed animals. Strains of the A22 subtype have been reported to change antigenically when adapted to different growth conditions. To investigate the structural basis of this phenomenon we have determined the structures of two variants of an A22 virus. PubMed: 8805520 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation