4GE5
Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 5
Summary for 4GE5
| Entry DOI | 10.2210/pdb4ge5/pdb |
| Related | 4GE2 4GE6 |
| Descriptor | Tyrosine-protein phosphatase non-receptor type 9, N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide (3 entities in total) |
| Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm (Probable): P43378 |
| Total number of polymer chains | 2 |
| Total formula weight | 73293.48 |
| Authors | Zhang, Z.-Y.,Liu, S.,Zhang, S. (deposition date: 2012-08-01, release date: 2012-10-31, Last modification date: 2023-09-13) |
| Primary citation | Zhang, S.,Liu, S.,Tao, R.,Wei, D.,Chen, L.,Shen, W.,Yu, Z.H.,Wang, L.,Jones, D.R.,Dong, X.C.,Zhang, Z.Y. A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134:18116-18124, 2012 Cited by PubMed: 23075115DOI: 10.1021/ja308212y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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