4GE5
Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 9 | polymer | 314 | 36229.1 | 2 | UniProt (P43378) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase MEG2, PTPase MEG2 |
| 2 | C (A) | N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide | non-polymer | 835.4 | 1 | Chemie (A89) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 356 | Chemie (HOH) |
Sequence modifications
A, B: 277 - 582 (UniProt: P43378)
| PDB | External Database | Details |
|---|---|---|
| Met 276 | - | initiating methionine |
| Ala 583 | - | expression tag |
| His 584 | - | expression tag |
| His 585 | - | expression tag |
| His 586 | - | expression tag |
| His 587 | - | expression tag |
| His 588 | - | expression tag |
| His 589 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72458.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 835.4 | |
| All* | Total formula weight | 73293.5 |
