4GAB
Human AKR1B10 mutant V301L complexed with NADP+ and fidarestat
Summary for 4GAB
Entry DOI | 10.2210/pdb4gab/pdb |
Related | 1ZUA |
Descriptor | Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, ... (5 entities in total) |
Functional Keywords | tim barrel, aldo-keto reductase, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: O60218 |
Total number of polymer chains | 1 |
Total formula weight | 37143.65 |
Authors | Cousido-Siah, A.,Ruiz Figueras, F.X.,Mitschler, A.,Podjarny, A. (deposition date: 2012-07-25, release date: 2013-03-20, Last modification date: 2023-09-13) |
Primary citation | Ruiz, F.X.,Cousido-Siah, A.,Mitschler, A.,Farres, J.,Pares, X.,Podjarny, A. X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity. Chem.Biol.Interact, 202:178-185, 2013 Cited by PubMed: 23295227DOI: 10.1016/j.cbi.2012.12.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5971 Å) |
Structure validation
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