4G9L

Structure of MMP3 complexed with NNGH inhibitor.

Summary for 4G9L

• Entry DOI: 10.2210/pdb4g9l/pdb
• Related: 4DPE 4JA1
• Descriptor: Stromelysin-1, ZINC ION, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: matrix metalloprotease, nngh, protease, hydroxamic zinc-chelating inhibitor, extracellular matrix, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix (Probable): P08254
• Total number of polymer chains: 2
• Total formula weight: 39651.53

Authors

Belviso, B.D.,Arnesano, F.,Calderone, V.,Caliandro, R.,Natile, G.,Siliqi, D. (deposition date: 2012-07-24, release date: 2013-05-29, Last modification date: 2023-09-13)

Primary citation

Belviso, B.D.,Caliandro, R.,Siliqi, D.,Calderone, V.,Arnesano, F.,Natile, G.
Structure of matrix metalloproteinase-3 with a platinum-based inhibitor.
Chem.Commun.(Camb.), 49:5492-5494, 2013

PubMed Abstract: An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1' specificity loop, representing the first step in the selective inhibition process (PDB ID code 4JA1).

PubMed: 23660647
DOI: 10.1039/c3cc41278d

Experimental method

X-RAY DIFFRACTION (1.88 Å)