4G9C

Human B-Raf Kinase Domain bound to a Type II Pyrazolopyridine Inhibitor

Summary for 4G9C

Entry DOI	10.2210/pdb4g9c/pdb
Related	4G9R
Descriptor	Serine/threonine-protein kinase B-raf, 3-{[3-(2-cyanopropan-2-yl)benzoyl]amino}-2,6-difluoro-N-(3-methoxy-2H-pyrazolo[3,4-b]pyridin-5-yl)benzamide (2 entities in total)
Functional Keywords	dfg-out, inhibitor, type ii, transferase, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus (By similarity): P15056
Total number of polymer chains	2
Total formula weight	71416.19
Authors	Voegtli, W.C.,Sturgis, H.L. (deposition date: 2012-07-23, release date: 2012-11-14, Last modification date: 2024-02-28)
Primary citation	Wenglowsky, S.,Moreno, D.,Laird, E.R.,Gloor, S.L.,Ren, L.,Risom, T.,Rudolph, J.,Sturgis, H.L.,Voegtli, W.C. Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors. Bioorg.Med.Chem.Lett., 22:6237-6241, 2012 Cited by PubMed: 22954737 DOI: 10.1016/j.bmcl.2012.08.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation