4G46

Structure of cytochrome P450 CYP121 in complex with 4-oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxylate

Summary for 4G46

Entry DOI	10.2210/pdb4g46/pdb
Related	4G44 4G45 4G47 4G48
Descriptor	Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ... (5 entities in total)
Functional Keywords	p450, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm (By similarity): P0A514
Total number of polymer chains	1
Total formula weight	44486.76
Authors	Hudson, S.A.,McLean, K.J.,Surade, S.,Yang, Y.-Q.,Leys, D.,Ciulli, A.,Munro, A.W.,Abell, C. (deposition date: 2012-07-16, release date: 2012-09-05, Last modification date: 2024-03-20)
Primary citation	Hudson, S.A.,McLean, K.J.,Surade, S.,Yang, Y.-Q.,Leys, D.,Ciulli, A.,Munro, A.W.,Abell, C. Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121 Angew.Chem.Int.Ed.Engl., 51:9311-9316, 2012 Cited by PubMed: 22890978 DOI: 10.1002/anie.201202544 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation