4G2R

Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor haloxyfop from Mycobacterium tuberculosis

4G2R の概要

• エントリーDOI: 10.2210/pdb4g2r/pdb
• 関連するPDBエントリー: 4FB8
• 分子名称: AccD6, Carboxyltransferase beta-subunit of Acyl-CoA Carboxylase, (2R)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (3 entities in total)
• 機能のキーワード: structural genomics, tb structural genomics consortium, tbsgc, crotonase super family, carboxyltransferase, transferase-herbicide complex, transferase, transferase-transferase inhibitor complex, psi-2, protein structure initiative, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 101844.67

構造登録者

Reddy, M.C.M.,Bruning, J.B.,Thurman, C.,Sherekar, M.,Valluru, S.,Ehrenfeld, H.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (登録日: 2012-07-12, 公開日: 2014-02-19, 最終更新日: 2023-09-13)

• 主引用文献: Reddy, M.C.,Breda, A.,Bruning, J.B.,Sherekar, M.,Valluru, S.,Thurman, C.,Ehrenfeld, H.,Sacchettini, J.C.; Structure, Activity, and Inhibition of the Carboxyltransferase beta-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis.; Antimicrob.Agents Chemother., 58:6122-6132, 2014; PubMed: 25092705; DOI: 10.1128/AAC.02574-13

実験手法

X-RAY DIFFRACTION (2.28 Å)