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4G2G

Crystal structure of Mycobacterium tuberculosis CYP121 in complex with 4,4'-(1H-1,2,3-triazole-1,5-diyl)diphenol

Summary for 4G2G
Entry DOI10.2210/pdb4g2g/pdb
Related4G1X
DescriptorCytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ... (6 entities in total)
Functional Keywordscytochrome p450, cyp, cyp121, oxidoreductase, cyy, c-c bond formation, assumed cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceMycobacterium tuberculosis
Cellular locationCytoplasm (By similarity): P0A514
Total number of polymer chains1
Total formula weight44584.93
Authors
Hudson, S.A. (deposition date: 2012-07-12, release date: 2012-09-05, Last modification date: 2023-11-08)
Primary citationHudson, S.A.,McLean, K.J.,Surade, S.,Yang, Y.-Q.,Leys, D.,Ciulli, A.,Munro, A.W.,Abell, C.
Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121
Angew.Chem.Int.Ed.Engl., 51:9311-9316, 2012
Cited by
PubMed: 22890978
DOI: 10.1002/anie.201202544
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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