4G2F

Human EphA3 kinase domain in complex with compound 7

4G2F の概要

• エントリーDOI: 10.2210/pdb4g2f/pdb
• 分子名称: EPH receptor A3, 1-amino-5-(5-hydroxy-2-methylphenyl)-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolin-6(5H)-one (3 entities in total)
• 機能のキーワード: receptor tyrosine kinase, atp binding, phosphorylation, membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40780.54

構造登録者

Dong, J.,Caflisch, A. (登録日: 2012-07-12, 公開日: 2012-10-24, 最終更新日: 2023-11-08)

• 主引用文献: Zhao, H.,Dong, J.,Lafleur, K.,Nevado, C.,Caflisch, A.; Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics.; ACS MED.CHEM.LETT., 3:834-838, 2012; PubMed: 24900387; DOI: 10.1021/ml3001984

実験手法

X-RAY DIFFRACTION (1.699 Å)