4G1Q

Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug

4G1Q の概要

• エントリーDOI: 10.2210/pdb4g1q/pdb
• 関連するPDBエントリー: 1S6Q 1SV5 2IC3 2ZD1 2ZE2 3BGR 3DLK 3V81
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (7 entities in total)
• 機能のキーワード: p51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, hiv, r278474, diarylpyrimidine, dapy, dna recombination, rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115306.17

構造登録者

Bauman, J.D.,Patel, D.,Das, K.,Arnold, E. (登録日: 2012-07-11, 公開日: 2013-02-06, 最終更新日: 2023-09-13)

• 主引用文献: Kuroda, D.G.,Bauman, J.D.,Challa, J.R.,Patel, D.,Troxler, T.,Das, K.,Arnold, E.,Hochstrasser, R.M.; Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase.; Nat Chem, 5:174-181, 2013; PubMed: 23422558; DOI: 10.1038/nchem.1559

実験手法

X-RAY DIFFRACTION (1.51 Å)