4G1N

PKM2 in complex with an activator

4G1N の概要

• エントリーDOI: 10.2210/pdb4g1n/pdb
• 分子名称: Pyruvate kinase isozymes M1/M2, OXALATE ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: pyruvate kinase, aerobic glycolysis, activator, cancer metabolism, phosphorylation of pyruvate, transferase-activator complex, transferase/activator
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P14618
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 228027.52

構造登録者

Kung, C.,Hixon, J.,Dang, L.,DeLaBarre, B.,Qian, K.C. (登録日: 2012-07-10, 公開日: 2012-10-10, 最終更新日: 2024-02-28)

• 主引用文献: Kung, C.,Hixon, J.,Choe, S.,Marks, K.,Gross, S.,Murphy, E.,Delabarre, B.,Cianchetta, G.,Sethumadhavan, S.,Wang, X.,Yan, S.,Gao, Y.,Fang, C.,Wei, W.,Jiang, F.,Wang, S.,Qian, K.,Saunders, J.,Driggers, E.,Woo, H.K.,Kunii, K.,Murray, S.,Yang, H.,Yen, K.,Liu, W.,Cantley, L.C.,Vander Heiden, M.G.,Su, S.M.,Jin, S.,Salituro, F.G.,Dang, L.; Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy.; Chem.Biol., 19:1187-1198, 2012; PubMed: 22999886; DOI: 10.1016/j.chembiol.2012.07.021

実験手法

X-RAY DIFFRACTION (2.3 Å)